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This may be explained by differences in body composition and should be taken into account when dosing or following factor VIII levels in the pediatric population.4 Because clearance (based on per kg body weight) has been demonstrated to be higher in the pediatric population, dose adjustment or more frequent dosing based on per kg body weight may be needed in this population [see Clinical Pharmacology (12.3)]

Intrauterine growth and the vitamin e status of full-term and preterm newborns

DNA catalysis: potential, limitations, open questions